Key Metrics

Mechanism of Action & Benefits

• One of the earliest colonizers of the gut in neonates and young animals, efficiently fermenting milk oligosaccharides and prebiotic oligosaccharides (such as galacto-oligosaccharides) to produce acetate
• Clinical and animal studies show that supplementation is associated with reduced incidence of necrotizing enterocolitis in preterm infants and neonatal animal models, reflecting a protective effect on the immature gut
• Secreted exopolysaccharides and surface pili support mucosal adhesion and colonization while suppressing pro-inflammatory signaling
• Shifts the local cytokine balance toward an anti-inflammatory profile in models of intestinal injury, lowering TNF-α and increasing IL-10
• In combination with prebiotic oligosaccharides, can modulate gene expression related to immunity and endocrine function in the neonatal gut
• Multiple trials confirm that administration in early life reduces the incidence and severity of eczema and atopic dermatitis symptoms

Recommended Dosage

Recommended minimum inclusion: 0.1–2×10⁸ CFU per kg body weight, adjusted by target species. For feed inclusion, calculate from body weight and target intake.