Key Metrics

Mechanism of Action & Benefits

• A spore-forming variant of Bacillus subtilis selected for high extracellular protease secretion, traditionally used as the starter culture for fermenting steamed soybeans into natto
• Produces nattokinase—a potent fibrinolytic serine protease shown in research to degrade fibrin and support healthy blood flow
• Synthesizes vitamin K2 (menaquinone-7) during fermentation, an important cofactor for proteins involved in bone and vascular health
• Generates bioactive metabolites with antioxidant activity, including pyrroloquinoline quinone (PQQ), as a fermentation byproduct
• High yields of protease, amylase, and lipase make it useful as an enzyme-source feed additive, improving nutrient breakdown and feed digestibility
• Forms heat- and acid-tolerant spores that withstand feed processing and gastrointestinal transit, germinating in the gut to exert both probiotic and enzymatic effects

Recommended Dosage

Recommended minimum inclusion: 0.1–2×10⁸ CFU per kg body weight, adjusted by target species. For feed inclusion, calculate from body weight and target intake.